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Chlordiazepoxide is a benzodiazepine used to treat withdrawal symptoms in acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a shorter period of time. buy chlordiazepoxide without a prescription

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative and amnesic properties. It has also been used for the symptomatic treatment of alcohol withdrawal.buy clopendex without prescription

Chlordiazepoxide is indicated for the treatment of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative anxiety and anxiety.

In combination with amitriptyline, chlordiazepoxide is indicated for the treatment of moderate to severe depression.7 In combination with clidinium, chlordiazepoxide is indicated for the control of emotional and somatic factors in gastrointestinal disorders and is used as adjunctive therapy in the treatment of peptic ulcer, irritable bowel syndrome, and acute enterocolitis.

Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA(A) receptor complexes at several sites in the central nervous system, including the limbic system and reticular formation. This results in increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor. BZDs therefore increase GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.

Chlordiazepoxide has anxiolytic, sedative, appetite stimulating, and weak analgesic effects. The drug appears to block EEG arousal from stimulation in the reticular formation of the brainstem. The drug has been studied extensively in many animal species, and these studies suggest effects on the limbic system of the brain, which recent evidence suggests is involved in emotional responses.

Hostile monkeys were tamed by oral doses of the drug that did not cause sedation. Chlordiazepoxide revealed a “taming” action with the elimination of fear and aggression.